Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC059
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-30 10:35
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment old patient Madopar 250mg 5x1 caps Madopar HBS 2x1 PK Merz 100mg 2x1 difficulties with spirala and elel

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 20 individuals with a value less than 0.58 were subsequently diagnosed with PD. That is, 47.62% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.58 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 24, 'TN': 19, 'TP': 18, 'FP': 11}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 20, 'TN': 17, 'TP': 22, 'FP': 13}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 5, 'TN': 3, 'TP': 37, 'FP': 27}

Test Battery Details

Circle

numCircles 5
timePerCircleMean 16.568
timePerCircleCoV 0.105477
timePerCircleSlope -0.0258329
meanError 5.46335
tremorFreq 7.32422
tremorRelPower 28.2855
tremorGyroAmpMean 0.0235292
tremorGyroAmpSlope 0.00499841
tremorGyroAmpCoV 0.415723
tremorCoordAmpMean 0.0450137
tremorCoordAmpSlope 0.00227488
tremorCoordAmpCoV 0.472274
tremorAccAmpMean 0.0339582
tremorAccAmpSlope 0.00183401
tremorAccAmpCoV 0.465858
tremorPcRelVar 0.660892
tremorPcX -0.227385
tremorPcY -0.973805

Circle Segment 1

Duration 17.4 s, Accuracy Estimate 3.899 (lower is better)

Circle Segment 2

Duration 16.36 s, Accuracy Estimate 5.586 (lower is better)

Circle Segment 3

Duration 16.24 s, Accuracy Estimate 6.439 (lower is better)

Circle Segment 4

Duration 18.8 s, Accuracy Estimate 5.488 (lower is better)

Circle Segment 5

Duration 14.04 s, Accuracy Estimate 5.905 (lower is better)

Spiral

numSpirals 3
timePerSpiralMean 59.6933
timePerSpiralCoV 0.119986
timePerSpiralSlope -0.11023
meanError 2.91567
tremorFreq 6.64062
tremorRelPower 32.9649
tremorGyroAmpMean 0.0318566
tremorGyroAmpSlope -0.00198574
tremorGyroAmpCoV 0.478362
tremorCoordAmpMean 0.0369551
tremorCoordAmpSlope 7.51837e-05
tremorCoordAmpCoV 0.333342
tremorAccAmpMean 0.0309685
tremorAccAmpSlope 0.000409948
tremorAccAmpCoV 0.389645
tremorPcRelVar 0.603393
tremorPcX 0.490703
tremorPcY 0.871327

Spiral Segment 1

Duration 64.64 s, Accuracy Estimate 3.245 (lower is better)

Spiral Segment 2

Duration 62.96 s, Accuracy Estimate 2.875 (lower is better)

Spiral Segment 3

Duration 51.48 s, Accuracy Estimate 2.628 (lower is better)

Elel

eDurationMean 0.605128
eDurationStd 0.228057
eDurationStdnorm 0.376873
eDurationMedian 0.6
eDurationQuartdelta 0.38
eDurationQuartdeltanorm 0.633333
eDurationKurt 2.03833
eDurationTrenddiff -0.325
eDurationTrendratio 0.566667
eWidthMean 3.024
eWidthStd 0.97909
eWidthStdnorm 0.323773
eWidthMedian 2.808
eWidthQuartdelta 1.49175
eWidthQuartdeltanorm 0.53125
eWidthKurt 3.67595
eWidthTrenddiff -0.936
eWidthTrendratio 0.741935
eHeightMean 7.458
eHeightStd 2.78736
eHeightStdnorm 0.373741
eHeightMedian 7.254
eHeightQuartdelta 4.5045
eHeightQuartdeltanorm 0.620968
eHeightKurt 2.01372
eHeightTrenddiff -3.627
eHeightTrendratio 0.597403
eAspectMean 0.439014
eAspectStd 0.154851
eAspectStdnorm 0.352726
eAspectMedian 0.414634
eAspectQuartdelta 0.199688
eAspectQuartdeltanorm 0.481601
eAspectKurt 3.79893
eAspectTrenddiff 0.0587121
eAspectTrendratio 1.14833
eSlantMean -0.0725846
eSlantStd 0.156614
eSlantStdnorm -2.15768
eSlantMedian -0.0909091
eSlantQuartdelta 0.230214
eSlantQuartdeltanorm -2.53236
eSlantKurt 2.70648
eSlantTrenddiff 0.0707804
eRtopMean 0.729564
eRtopStd 0.175523
eRtopStdnorm 0.240586
eRtopMedian 0.75
eRtopQuartdelta 0.222906
eRtopQuartdeltanorm 0.297208
eRtopKurt 2.45529
eRtopTrenddiff -0.0108696
eRbotMean 0.960917
eRbotStd 0.426994
eRbotStdnorm 0.444361
eRbotMedian 0.923077
eRbotQuartdelta 0.478658
eRbotQuartdeltanorm 0.518546
eRbotKurt 3.87634
eRbotTrenddiff -0.0857143
eRrightMean 0.791355
eRrightStd 0.192377
eRrightStdnorm 0.243098
eRrightMedian 0.870968
eRrightQuartdelta 0.282408
eRrightQuartdeltanorm 0.324247
eRrightKurt 3.2492
eRrightTrenddiff -0.0175439
eRleftMean 0.420322
eRleftStd 0.143605
eRleftStdnorm 0.341655
eRleftMedian 0.397436
eRleftQuartdelta 0.206003
eRleftQuartdeltanorm 0.518331
eRleftKurt 2.47216
eRleftTrenddiff -0.0119215
lDurationMean 0.764861
lDurationStd 0.159971
lDurationStdnorm 0.20915
lDurationMedian 0.7375
lDurationQuartdelta 0.125
lDurationQuartdeltanorm 0.169492
lDurationKurt 5.85653
lDurationTrenddiff -0.025
lDurationTrendratio 0.966443
lWidthMean 4.901
lWidthStd 0.990324
lWidthStdnorm 0.202066
lWidthMedian 4.914
lWidthQuartdelta 1.404
lWidthQuartdeltanorm 0.285714
lWidthKurt 3.45613
lWidthTrenddiff -0.0585
lWidthTrendratio 0.988235
lHeightMean 18.2747
lHeightStd 2.19562
lHeightStdnorm 0.120145
lHeightMedian 18.486
lHeightQuartdelta 3.042
lHeightQuartdeltanorm 0.164557
lHeightKurt 2.37683
lHeightTrenddiff 0.585
lHeightTrendratio 1.03236
lAspectMean 0.270324
lAspectStd 0.0578641
lAspectStdnorm 0.214055
lAspectMedian 0.265235
lAspectQuartdelta 0.0768776
lAspectQuartdeltanorm 0.289847
lAspectKurt 3.76825
lAspectTrenddiff -0.00427261
lAspectTrendratio 0.983891
lSlantMean -0.0313902
lSlantStd 0.110223
lSlantStdnorm -3.51137
lSlantMedian -0.019592
lSlantQuartdelta 0.117036
lSlantQuartdeltanorm -5.97363
lSlantKurt 3.39824
lSlantTrenddiff 0.0519729
lRtopMean 0.697646
lRtopStd 0.13354
lRtopStdnorm 0.191416
lRtopMedian 0.733202
lRtopQuartdelta 0.204987
lRtopQuartdeltanorm 0.279577
lRtopKurt 2.54411
lRtopTrenddiff -0.000295418
lRbotMean 0.84671
lRbotStd 0.396112
lRbotStdnorm 0.467825
lRbotMedian 0.77033
lRbotQuartdelta 0.463211
lRbotQuartdeltanorm 0.601315
lRbotKurt 5.44788
lRbotTrenddiff -0.114306
lRrightMean 0.837977
lRrightStd 0.0839029
lRrightStdnorm 0.100126
lRrightMedian 0.862467
lRrightQuartdelta 0.11208
lRrightQuartdeltanorm 0.129953
lRrightKurt 3.6048
lRrightTrenddiff -0.0622793
lRleftMean 0.470871
lRleftStd 0.184409
lRleftStdnorm 0.391633
lRleftMedian 0.486726
lRleftQuartdelta 0.237575
lRleftQuartdeltanorm 0.488108
lRleftKurt 2.34035
lRleftTrenddiff 0.0284791

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.689821
sumTouchScores 9.6575
meanMovementTime 1.25192
numTouches 14
undershootPercentage 7.14286
overshootPercentage 28.5714

FITTS Long Modified

meanTouchScore 0.850592
sumTouchScores 9.35651
meanMovementTime 1.7885
numTouches 11
undershootPercentage 9.09091
overshootPercentage 9.09091

ZigZag

numZigzags 8
timePerZigzagMean 30.765
timePerZigzagCoV 0.174762
timePerZigzagSlope -0.0102002
meanError 2.50047
tremorFreq 6.64062
tremorRelPower 45.0576
tremorGyroAmpMean 0.0514835
tremorGyroAmpSlope 0.00118923
tremorGyroAmpCoV 0.453221
tremorCoordAmpMean 0.0713361
tremorCoordAmpSlope 0.000219411
tremorCoordAmpCoV 0.676098
tremorAccAmpMean 0.0527964
tremorAccAmpSlope 0.0010156
tremorAccAmpCoV 0.431484
tremorPcRelVar 0.74833
tremorPcX -0.165369
tremorPcY -0.986232

ZigZag Segment 1

Duration 40.64 s, Accuracy Estimate 2.744 (lower is better)

ZigZag Segment 2

Duration 25.48 s, Accuracy Estimate 2.449 (lower is better)

ZigZag Segment 3

Duration 33.04 s, Accuracy Estimate 2.316 (lower is better)

ZigZag Segment 4

Duration 26.8 s, Accuracy Estimate 2.245 (lower is better)

ZigZag Segment 5

Duration 26.36 s, Accuracy Estimate 2.501 (lower is better)

ZigZag Segment 6

Duration 26.48 s, Accuracy Estimate 2.476 (lower is better)

ZigZag Segment 7

Duration 32.8 s, Accuracy Estimate 2.448 (lower is better)

ZigZag Segment 8

Duration 34.52 s, Accuracy Estimate 2.826 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 23.312
timePerZigzagCoV 0.0955301
timePerZigzagSlope -0.049245
zigzagHeightMean 67.2973
zigzagHeightCoV 0.0610766
zigzagHeightSlope -0.0144279
meanError 0.0248466
tremorFreq 6.64062
tremorRelPower 36.8665
tremorGyroAmpMean 0.0408285
tremorGyroAmpSlope 0.000425941
tremorGyroAmpCoV 0.446515
tremorCoordAmpMean 0.0681876
tremorCoordAmpSlope 0.00168906
tremorCoordAmpCoV 0.343721
tremorAccAmpMean 0.0508807
tremorAccAmpSlope 0.000838118
tremorAccAmpCoV 0.397695
tremorPcRelVar 0.771807
tremorPcX 0.312618
tremorPcY -0.949879

ZigZag Offset Segment 1

Duration 26.88 s, Accuracy Estimate 0.024 (lower is better)

ZigZag Offset Segment 2

Duration 23.2 s, Accuracy Estimate 0.022 (lower is better)

ZigZag Offset Segment 3

Duration 22.0 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 4

Duration 23.48 s, Accuracy Estimate 0.022 (lower is better)

ZigZag Offset Segment 5

Duration 21.0 s, Accuracy Estimate 0.03 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.58}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.4080659780712048}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8420347181665166}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.6635103089489831}